GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10935120 | 1 | rs7433663 | chr3:134235790 | CEP63 | chr3:134204575-134293852:+ | 0.22 | 3.87 | 0.000127 | Height |
| BLCA | cis | rs10935120 | 1 | rs7433991 | chr3:134312292 | ANAPC13 | chr3:134196547-134204865:- | 0.48 | 7.6 | 2.33E-13 | Height |
| BLCA | cis | rs6951245 | 1 | rs74347384 | chr7:1072440 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.31 | 2.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs2273 | 1 | rs7436021 | chr4:76905472 | NAAA | chr4:76831809-76862166:- | -0.39 | -6.41 | 4.28E-10 | Longevity |
| BLCA | cis | rs6951245 | 1 | rs74366004 | chr7:1088630 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.53 | 7.9E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs74369356 | chr7:1071711 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.31 | 2.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs7444 | 1 | rs7444 | chr22:21976934 | CCDC116 | chr22:21987086-21991615:+ | -0.25 | -3.88 | 0.000121 | Systemic lupus erythematosus |
| BLCA | cis | rs9910950 | 1 | rs74531840 | chr17:64176115 | AXIN2 | chr17:63524685-63637183:- | 0.54 | 4.54 | 7.41E-6 | Presence of antiphospholipid antibodies |
| BLCA | cis | rs11782652 | 1 | rs74544416 | chr8:82657745 | CHMP4C | chr8:82644688-82671746:+ | -0.78 | -7.43 | 7.2E-13 | Epithelial ovarian cancer;Ovarian cancer |
| BLCA | cis | rs2243480 | 1 | rs7456042 | chr7:65299778 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.48 | 1.0E-5 | Diabetic kidney disease |
| BLCA | cis | rs2241437 | 1 | rs74607112 | chr2:86305534 | LOC90784 | chr2:86247339-86250991:- | -0.38 | -3.92 | 0.000106 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| BLCA | cis | rs6951245 | 1 | rs74652290 | chr7:1090109 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.35 | 1.76E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs477692 | 1 | rs7475154 | chr10:131440584 | MGMT | chr10:131265454-131565783:+ | -0.23 | -4.92 | 1.27E-6 | Response to temozolomide |
| BLCA | cis | rs11782652 | 1 | rs74758321 | chr8:82667320 | CHMP4C | chr8:82644688-82671746:+ | -0.76 | -7.15 | 4.34E-12 | Epithelial ovarian cancer;Ovarian cancer |
| BLCA | cis | rs6951245 | 1 | rs74785791 | chr7:1088494 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.53 | 7.9E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |